The Gunners could turn to Noni Madueke to fill the void, while Martin Odegaard, Jurrien Timber and Riccardo Calafiori have not been ruled out to play yet.
Hosts City have no fresh injury concerns, with Nico O'Reilly deemed fine to play despite being substituted with a hamstring complaint during last Sunday's win at Chelsea.
Elsewhere, Liverpool forward Hugo Ekitike will begin a lengthy spell out as he recovers from a ruptured Achilles tendon, picked up in the Reds' Champions League exit to Paris Saint-Germain on Tuesday.
Tottenham will be without captain Cristian Romero against Brighton and for the rest of the season after he sustained a serious knee injury in their defeat at Sunderland.
Find out who's missing, doubtful or suspended for this weekend's Premier League action:
Brentford vs Fulham (Saturday, 13:30)
WON'T PLAY
Carvalho | Knee Injury
Dasilva | Knee Injury
Henderson | Knock
Janelt | Foot Injury
Milambo | Knee Injury
Kevin | Foot Injury
DOUBTFUL
Henry | Muscle Injury
Hickey | Hamstring Injury
Reed | Knock
Tete | Foot Injury
Leeds vs Wolves (Saturday, 16:00)
WON'T PLAY
James | Muscle Injury
Rodon | Ankle Injury
Stach | Ankle Injury
Chiwome | Knee Injury
Gonzalez | Knee Injury
Mosquera | Yellow Cards
DOUBTFUL
Doherty | Inactive
Johnstone | Knock
Newcastle vs Bournemouth (Saturday, 16:00)
WON'T PLAY
Bruno Guimaraes | Muscle Injury
Joelinton | Yellow Cards
Krafth | Knee Injury
Schar | Ankle Injury
Cook | Hamstring Injury
Kluivert | Knee Injury
DOUBTFUL
Soler | Hamstring Injury
Tottenham vs Brighton (Saturday, 18:30)
WON'T PLAY
Davies | Ankle Injury
Kudus | Muscle Injury
Kulusevski | Knee Injury
Maddison | Knee Injury
Odobert | Knee Injury
Romero | Knee Injury
Vicario | Groin Injury
Dunk | Yellow Cards
Milner | Injury
Tzimas | Knee Injury
Webster | Knee Injury
Chelsea vs Manchester United (Saturday, 21:00)
WON'T PLAY
Colwill | Knee Injury
Gittens | Muscle Injury
James | Hamstring Injury
Jorgensen | Groin Injury
Mudryk | Suspended
De Ligt | Back Injury
Dorgu | Hamstring Injury
Maguire | Suspended
Martinez | Red Card
DOUBTFUL
Chalobah | Ankle Injury
Aston Villa vs Sunderland (Sunday, 15:00)
WON'T PLAY
Kamara | Knee Injury
Bi | Ankle Injury
Mundle | Hamstring Injury
Traore | Knee Injury
DOUBTFUL
Alysson | Injury
Angulo | Muscle Injury
Ballard | Muscle Injury
Everton vs Liverpool (Sunday, 15:00)
WON'T PLAY
Grealish | Foot Injury
Alisson | Muscle Injury
Bajcetic | Hamstring Injury
Bradley | Knee Injury
Ekitike | Achilles Tendon Injury
Endo | Foot Injury
Gomez | Injury
Leoni | Knee Injury
DOUBTFUL
Alcaraz | Injury
Nottingham Forest vs Burnley (Sunday, 15:00)
WON'T PLAY
Boly | Knee Injury
John Victor | Knee Injury
Savona | Knee Injury
Amdouni | Knee Injury
Beyer | Hamstring Injury
Cullen | Knee Injury
Mejbri | Hamstring Injury
Roberts | Muscle Injury
DOUBTFUL
Anderson | Personal Reasons
Hudson-Odoi | Injury
Murillo | Injury
Wood | Injury
Manchester City vs Arsenal (Sunday, 17:30)
WON'T PLAY
Dias | Muscle Injury
Gvardiol | Broken Leg
Stones | Calf Injury
Merino | Foot Injury
Saka | Injury
DOUBTFUL
Calafiori | Knock
Madueke | Injury
Odegaard | Muscle Injury
Timber | Ankle Injury
Crystal Palace vs West Ham (Monday, 21:00)
WON'T PLAY
TBC
TBC
DOUBTFUL
TBC