Spurs lost Romero to injury during the warm-up for their 2-1 home defeat to Aston Villa last time out, and the Argentine defender missed the London side's 0-0 draw with Monaco in the Champions League in midweek.
Elsewhere, Newcastle are set to continue to be without Tino Livramento and Yoane Wissa when they host Fulham on Saturday, while Manchester United are hoping Brazilian midfielder Casemiro may play a part as they look to build on the momentum of last week's shock Anfield win against Liverpool.
See who's missing, doubtful or suspended ahead of this weekend's Premier League fixtures:
Leeds vs West Ham
WILL NOT PLAY
Gray H. | Hip injury
Earthy G. | Hamstring injury
Fullkrug N. | Thigh injury
Mavropanos K. | Injury
QUESTIONABLE
Ampadu E. | Illness
Gnonto W. | Hernia
Okafor N. | Muscle injury
Struijk P. | Illness
Chelsea vs Sunderland
WILL NOT PLAY
Badiashile B. | Muscle injury
Colwill L. | Knee injury
Delap L. | Hamstring injury
Essugo D. | Thigh injury
Gusto M. | Red card
Mudryk M. | Suspended
Palmer C. | Groin injury
Alese A. | Shoulder injury
Cirkin D. | Wrist injury
Diarra H. | Groin injury
Hjelde L. F. | Achilles tendon injury
Mundle R. | Hamstring injury
QUESTIONABLE
Alderete O. | Head Injury
Newcastle vs Fulham
WILL NOT PLAY
Hall L. | Thigh Injury
Livramento V. | Knee injury
Wissa Y. | Knee injury
Andersen J. | Injury
Chukwueze S. | Calf injury
Rodrigo Muniz | Muscle injury
QUESTIONABLE
Robinson A. | Knee injury
Wilson H. | Knock
Manchester United vs Brighton
WILL NOT PLAY
Martinez Li. | Knee injury
Hinshelwood J. | Ankle injury
March S. | Knee injury
Webster A. | Knee injury
QUESTIONABLE
Gruda B. | Knee injury
Mitoma K. | Ankle Injury
Veltman J. | Calf injury
Brentford vs Liverpool
WILL NOT PLAY
Maghoma P. | Thigh Injury
Milambo A. | Knee injury
Alisson | Groin injury
Bajcetic S. | Hamstring injury
Chambers L. | Back injury
Frimpong J. | Hamstring injury
Leoni G. | Knee injury
Scanlon C. | Hamstring injury
QUESTIONABLE
Hickey A. | Knee injury
Gravenberch R. | Ankle injury
Isak A. | Groin injury
Arsenal vs Crystal Palace
WILL NOT PLAY
Gabriel Jesus | Knee injury
Havertz K. | Knee injury
Madueke N. | Knee injury
Odegaard M. | Knee injury
Doucoure C. | Knee injury
Kporha C. | Back injury
Riad C. | Knee injury
Aston Villa vs Manchester City
WILL NOT PLAY
Garcia A. | Inactive
Tielemans Y. | Calf injury
Khusanov A. | Ankle injury
Rodri | Hamstring injury
QUESTIONABLE
Digne L. | Injury
Nico | Injury
Bournemouth vs Nottingham Forest
WILL NOT PLAY
Brooks D. | Hamstring injury
Evanilson | Calf injury
Unal E. | Knee injury
Aina O. | Hamstring injury
Bakwa D. | Injury
Zinchenko O. | Muscle Injury
QUESTIONABLE
Wood C. | Injury
Wolves vs Burnley
WILL NOT PLAY
Chiwome L. | Knee injury
Amdouni Z. | Knee injury
Beyer J. | Hamstring injury
Roberts C. | Groin injury
QUESTIONABLE
Bellegarde J. | Illness
Hwang Hee-Chan | Injury
Foster L. | Knock
Everton vs Tottenham
WILL NOT PLAY
Branthwaite J. | Thigh injury
Bissouma Y. | Ankle injury
Davies B. | Muscle injury
Dragusin R. | Knee injury
Kulusevski D. | Knee injury
Maddison J. | Knee injury
Romero C. | Muscle injury
Solanke D. | Ankle injury
Takai K. | Foot injury
Udogie D. | Knee injury
QUESTIONABLE
Patterson N. | Injury