Former rugby league star Suaalii's inclusion sees him returning to the scene of his Test debut last year, a match where Jorgensen's try with the last play of the game sealed a dramatic 42-37 win for Australia.
Suaalii takes his spot at outside centre alongside Hunter Paisami, with Len Ikitau, who plays his club rugby for English side Exeter, still unavailable as this match takes place outside the international window.
Jorgensen partners Harry Potter on the wing, with Andrew Kellaway retaining his place at full-back.
Regular captain Harry Wilson returns to the back row with Nick Champion de Crespigny, last week's skipper, among the replacements.
Elsewhere in the forwards, Tupou and Billy Pollard reunite in the front row.
Nick Frost and Jeremy Williams link up once again as the two locks, with Lukhan Salakaia-Loto overcoming a rib injury to feature on the bench.
"The group travelled well to London earlier in the week and have had a couple of trainings ahead of this weekend's Test," said Australia coach Joe Schmidt.
"The coaches have tried to balance this year's tough schedule in terms of Test matches and travel, so it was great to freshen a few players up last week and we hope that allows the group to be really competitive on Saturday."
Australia squad to face England:
(15-1): Andrew Kellaway; Max Jorgensen, Joseph-Aukuso Suaalii, Hunter Paisami, Harry Potter; Tane Edmed, Jake Gordon; Harry Wilson (capt), Fraser McReight, Rob Valentini; Jeremy Williams, Nick Frost; Taniela Tupou, Billy Pollard, Angus Bell
Replacements: Josh Nasser, Tom Robertson, Allan Alaalatoa, Lukhan Salakaia-Loto, Nick Champion de Crespigny, Ryan Lonergan, Hamish Stewart, Filipo Daugunu