The defensive-dominated victory lifted Denver to an NFL-best record of 8-2 and boosted their lead atop the AFC West division over the Los Angeles Chargers (6-3) with their longest win streak since 2015.
The Broncos, whose defenders made six sacks and an interception, improved to 5-0 at home this season with their 10th consecutive win at Mile High Stadium, joining Indianapolis as the only clubs without a home defeat this year.
"We have a really good defense and they showed up again tonight," Nix said. "We didn't give them the best of fields at times but they still made plays and kept them out of field goal range."
"They keep winning games for us and getting us the ball back and at some point we have to return to favor."
The Broncos' next game, and only contest in the next 23 days thanks to a bye week, will be at home on November 16 against division rival Kansas City (5-4).
"We've got a lot of work to do," Nix said. "But we're winning and that's all that matters."
Ashton Jeanty's four-yard touchdown run 11:58 into the game put Las Vegas ahead, but defences dominated from there.
Denver, the NFL leaders in quarterback sacks, brought down the Raiders' Geno Smith to seize possession on downs near midfield with 5:58 remaining in the second quarter.
On the next play, the Broncos got their first first down of the game and just four plays later, Nix flipped a seven-yard touchdown pass to Troy Franklin and the hosts pulled level 7-7.
It stretched Nix's streak of games with a touchdown pass to 18.
The Broncos got a break when J.L. Skinner, using his facemask, blocked a kick by Vegas punter A.J. Cole to put the Broncos at the Raiders' 12-yard line,.
Despite the Raiders forcing a quick fourth down, a 32-yard Wil Lutz field goal put Denver up 10-7 heading into the half.
Kyu Blu Kelly intercepted a Nix pass for the second time in the game to set up the Raiders (2-7) at the Denver 45-yard line with 7:16 remaining.
But Daniel Carlson was wide right on a 48-yard field goal attempt and the Broncos kept the lead with 4:26 remaining.
Denver took the ball and ran out the clock. Running back J.K. Dobbins led all running backs with 77 yards on 18 carries.
Nix finished 150 passing yards, one touchdown, and two interceptions on 16-of-28 passing.
Geno Smith finished with 143 passing yards and an interception on 16-of-26 passing. Jeanty would finish the game 60 rushing yards on 19 carries.
Denver put up 220 yards of total offence, the Raiders just 188.
22 penalties were thrown (11 for each team), eight sacks were recorded, and three turnovers were forced, making it one of the worst games of the 2025 NFL season.
A moment of silence was observed before the game for Dallas Cowboys defensive end Marshawn Kneeland, who died Thursday at age 24.