It will be a career-high weight for Crawford, a four-division champion who is jumping up two weight classes to the 168-pound division to face Alvarez in hopes of becoming the first man with undisputed crowns in three different categories.
Crawford 41-0 with 31 knockouts, has owned all four belts in the super lightweight and welterweight divisions.
But the 37-year-old southpaw steps into the ring at Allegiant Stadium, home of the NFL's Las Vegas Raiders, as an underdog to 35-year-old Mexican star Alvarez, who is 63-2-2 with 39 knockouts.
Alvarez, also a four-division champion, is the only fighter to hold all four major belts in the super middleweight division.
He has won six fights in a row since stepping up to light heavyweight in May 2022 and losing a unanimous decision to Russian Dmitry Bivol.